Mutagen Talent Tree: Every Talent and Rank

The Mutagen tree is for Mutated Anomaly builds and anyone who likes poison: toxic blood that damages every enemy each round, vampiric healing and organic armor.

11TALENTS

47POINTS TO MASTER

6TIERS

TIER 1 · UNLOCKS AT 0 POINTS IN THIS TREE

Toxic Blood

5 RANKS · 1 POINT EACH

Poison all enemies for 1% of their HP each round

At max rank: Poison all enemies for 5% of their HP each round

Bloodtap

5 RANKS · 1 POINT EACH

1% of damage dealt heals you

At max rank: 5% of damage dealt heals you

Mutant Hide

5 RANKS · 1 POINT EACH

+2 Armor

At max rank: +10 Armor

TIER 2 · UNLOCKS AT 3 POINTS IN THIS TREE

Rad Resist

5 RANKS · 1 POINT EACH

1% Damage Reduction

At max rank: 5% Damage Reduction

Requires: Mutant Hide rank 1

Hardened Marrow

5 RANKS · 1 POINT EACH

+2% Max HP

At max rank: +10% Max HP

Requires: Mutant Hide rank 2

Acid Spit

5 RANKS · 1 POINT EACH

+2% Damage

At max rank: +10% Damage

Requires: Toxic Blood rank 2

TIER 3 · UNLOCKS AT 7 POINTS IN THIS TREE

Adaptive Organs

3 RANKS · 1 POINT EACH

Regenerate 1% max HP each combat round

At max rank: Regenerate 3% max HP each combat round

Requires: Hardened Marrow rank 2

Plague Carrier

3 RANKS · 1 POINT EACH

Poison all enemies for 2% of their HP each round

At max rank: Poison all enemies for 6% of their HP each round

Requires: Toxic Blood rank 4

TIER 4 · UNLOCKS AT 12 POINTS IN THIS TREE

Unstable Genome

5 RANKS · 1 POINT EACH

+3% Critical Chance

At max rank: +15% Critical Chance

Requires: Acid Spit rank 3

Bloodsurge

3 RANKS · 1 POINT EACH

2% of damage dealt heals you

At max rank: 6% of damage dealt heals you

Requires: Bloodtap rank 4

TIER 6 · UNLOCKS AT 25 POINTS IN THIS TREE · CAPSTONE

Apex Mutation

1 RANK · 3 POINTS EACH

Poison all enemies for 4% of their HP each round
5% of damage dealt heals you
Regenerate 2% max HP each combat round
+10% Max HP

At max rank: Poison all enemies for 4% of their HP each round, 5% of damage dealt heals you, Regenerate 2% max HP each combat round, +10% Max HP

Requires: Plague Carrier rank 3, Bloodsurge rank 3

The capstone

Apex Mutation costs 3 points and gives: Poison all enemies for 4% of their HP each round; 5% of damage dealt heals you; Regenerate 2% max HP each combat round; +10% Max HP. To take it you need Plague Carrier at rank 3, Bloodsurge at rank 3, and 25 points spent in the tree. Plan your path backwards from the capstone: spend your early points on the talents it requires, then fill in the rest.

Pairs well with

Mutagen works best alongside Berserker and Juggernaut. Berserker adds more lifesteal and damage when you are low, and Juggernaut offsets the HP you lose to the Mutated Anomaly background.

See all trees on the talent overview, check the gear that supports this tree in the item database and read the five complete builds.